Central nervous system (CNS) metastasis from systemic cancers can involve the brain
parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura.
Leptomeningeal metastases (LM), also known by different terms including neoplastic
meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic
malignancies. This review will focus exclusively on LM arising from solid tumors with a goal
of providing the reader an understanding of the epidemiology, pathophysiology, clinical …